Playing with dopamine release
نویسندگان
چکیده
منابع مشابه
Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals.
Drugs of abuse hijack brain-reward circuitry during the addiction process by augmenting action potential-dependent phasic dopamine release events associated with learning and goal-directed behavior. One prominent exception to this notion would appear to be amphetamine (AMPH) and related analogs, which are proposed instead to disrupt normal patterns of dopamine neurotransmission by depleting ves...
متن کاملDopamine release at individual presynaptic terminals visualized with FFNs.
The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. To observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter. Using these probes to image dopamine release in the striatum, we made several ...
متن کاملChanges in dopamine release and dopamine D2/3 receptor levels with the development of mild obesity.
Dopamine (DA) neurotransmission is an important modulator of both homeostatic food consumption mediated by the hypothalamus, and reward-related/ hedonic food consumption mediated by the brain reward circuit (Lutter and Nestler, 2009; Schwartz et al., 2000; Wise, 2008). Although there are monogenetic mutations that affect the regulation of body weight, the majority of cases of human obesity appe...
متن کاملRecovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release
Methamphetamine's widepread abuse and concerns that it might increase Parkinson's disease led us to assess if the reported loss of dopamine transporters (DAT) in methamphetamine abusers (MA) reflected damage to dopamine neurons. Using PET with [(11)C]cocaine to measure DAT, and with [(11)C]raclopride to measure dopamine release (assessed as changes in specific binding of [(11)C]raclopride betwe...
متن کاملAnomalous dopamine release associated with a human dopamine transporter coding variant.
Dopamine (DA) signaling at synapses is tightly coordinated through opposing mechanisms of vesicular fusion-mediated DA release and transporter-mediated DA clearance. Altered brain DA signaling is suspected to underlie multiple brain disorders, including schizophrenia, Parkinson's disease, bipolar disorder, and attention-deficit hyperactivity disorder (ADHD). We identified a pedigree containing ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1998
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0698-660